Turkish Journal of Pharmaceutical Sciences

The Cardiopulmonary Effects of Calcitonin-Gene Related Peptide Family [Turk J Pharm Sci]
Turk J Pharm Sci. 2020; 17(3): 349-356

The Cardiopulmonary Effects of Calcitonin-Gene Related Peptide Family

GOKÇEN TELLI1, BANU CAHIDE TEL1, BÜLENT GÜMÜSEL2
1Hacettepe University Faculty of Pharmacy Department of Pharmacology
2Lokman Hekim University Faculty of Pharmacy Department of Pharmacology

The cardiopulmonary diseases are very common in the population. They are high-cost diseases and there are still no definitive treatments. The roles of members of the calcitonin-gene-related peptide (CGRP) family in the cardiopulmonary diseases have been studied for many years and promising results are obtained. Especially in recent years, two important members of the family, adrenomedullin and adrenomedullin2/intermedin, are considered as new treatment targets in cardiopulmonary diseases. In this review, the roles of CGRP family peptides in cardiopulmonary diseases has been investigated according to the studies that were performed to the present day.

Keywords: CGRP family, cardiopulmonary diseases, adrenomedullin, adrenomedullin2/intermedin, pulmonary hypertension


Kalsitonin-Geni İle İlişkili Peptit Ailesinin Kardiyopulmoner Etkileri

GOKÇEN TELLI1, BANU CAHIDE TEL1, BÜLENT GÜMÜSEL2
1Hacettepe Üniversitesi Eczacılık Fakültesi Farmakoloji Anabilim Dalı
2Lokman Hekim Üniversitesi Eczacılık Fakültesi Farmakoloji Anabilim Dalı

Kardiyopulmoner hastalıklar toplumda sık görülen, tedavi maliyeti oldukça yüksek ve halen kesin bir tedavisi bulunmayan hastalıklardır. Kalsitonin-geni ile ilişkili peptit ailesinin üyelerinin bir çok kardiyopulmoner hastalıktaki rolleri uzun yıllardır çalışılmakta ve umut vadeden sonuçlar elde edilmektedir. Özellikle son yıllarda CGRP ailesine ait peptitlerden adrenomedullin ve intermedin kardiyopulmoner hastalıklarda yeni tedavi hedefleri olarak değerlendirilmektedir. Bu derleme ile CGRP ailesi peptitlerinin kardiyopulmoner hastalıklardaki roller günümüze kadar yapılan çalışmalar doğrultusunda incelenmiştir.

Anahtar Kelimeler: CGRP ailesi, kardiyopulmoner hastalıklar, adrenomedullin, adrenomedullin2/intermedin, pulmoner hipertansiyon


GOKÇEN TELLI, BANU CAHIDE TEL, BÜLENT GÜMÜSEL. The Cardiopulmonary Effects of Calcitonin-Gene Related Peptide Family. Turk J Pharm Sci. 2020; 17(3): 349-356

Corresponding Author: BÜLENT GÜMÜSEL, Türkiye


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