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Turkish Journal of Pharmaceutical Sciences
| Turk J Pharm Sci. 2016; 13(1): 84-94 | DOI: 10.5505/tjps.2016.55265 | |||
Chemical Composition, Antioxidant and Cytotoxicity Potential of Daniellia oliveri (Rolfe) Hutch. & Dalz.Olubunmi Atolanı1, Gabriel A. Olatunjı21Department Of Chemistry, University Of Ilorin, P.m.b. 1515, Ilorin, Nigeria2Department Of Industrial Chemistry, University Of Ilorin, P.m.b. 1515, Ilorin, Nigeria The chemical composition of the oleoresin from Daniellia oliveri (Rolfe) Hutch. & Dalz. of the family Caesalpiniaceae was determined using GC-FID/GC-MS and its potentials as antioxidant and cytotoxity evaluated for the first time. The GC-MS analysis revealed the major constituents of the resin as volatile diterpenoids. The major compounds include δ-cadinene (42.92%), copaene (11.36%), cis-muurola-4(14),5-diene (9.56%), polyalthic acid (4.6%), β-calacorene (4.37%), 2(5H)-Furanone-5-(2,5-dimethylphenyl)-4-methyl- (4.35%) and aromadendrene (4.14%). A significant antioxidant activity (IC50= 15.49 ± 0.39 mg/mL) and low cytotoxicity (IC50 > 30 µg/ml) on prostate cancer cell line was obtained for the oleoresin. The low cytotoxicity and moderate antioxidant potential of the oleoresin from D. oliveri is an indication of possible application in related in vivo studies for future therapeutic applications. The major compounds being sesquiterpenes could be used as a biomarker for the chemotaxonomical characterization of the species. Keywords: Cadinene, Copaene, Daniellia oliveri, Diterpenoids, Cytotoxicity and AntioxidantChemical Composition, Antioxidant and Cytotoxicity Potential of Daniellia oliveri (Rolfe) Hutch. & Dalz.Olubunmi Atolanı1, Gabriel A. Olatunjı21Department Of Chemistry, University Of Ilorin, P.m.b. 1515, Ilorin, Nigeria2Department Of Industrial Chemistry, University Of Ilorin, P.m.b. 1515, Ilorin, Nigeria The chemical composition of the oleoresin from Daniellia oliveri (Rolfe) Hutch. & Dalz. of the family Caesalpiniaceae was determined using GC-FID/GC-MS and its potentials as antioxidant and cytotoxity evaluated for the first time. The GC-MS analysis revealed the major constituents of the resin as volatile diterpenoids. The major compounds include δ-cadinene (42.92%), copaene (11.36%), cis-muurola-4(14),5-diene (9.56%), polyalthic acid (4.6%), β-calacorene (4.37%), 2(5H)-Furanone-5-(2,5-dimethylphenyl)-4-methyl- (4.35%) and aromadendrene (4.14%). A significant antioxidant activity (IC50= 15.49 ± 0.39 mg/mL) and low cytotoxicity (IC50 > 30 µg/ml) on prostate cancer cell line was obtained for the oleoresin. The low cytotoxicity and moderate antioxidant potential of the oleoresin from D. oliveri is an indication of possible application in related in vivo studies for future therapeutic applications. The major compounds being sesquiterpenes could be used as a biomarker for the chemotaxonomical characterization of the species. Anahtar Kelimeler: Cadinene, Copaene, Daniellia oliveri, Diterpenoids, Cytotoxicity and AntioxidantOlubunmi Atolanı, Gabriel A. Olatunjı. Chemical Composition, Antioxidant and Cytotoxicity Potential of Daniellia oliveri (Rolfe) Hutch. & Dalz.. Turk J Pharm Sci. 2016; 13(1): 84-94 Corresponding Author: Olubunmi Atolanı, Nigeria |
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