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Turkish Journal of Pharmaceutical Sciences
| Turk J Pharm Sci. 2016; 13(2): 105-123 | DOI: 10.5505/tjps.2016.05706 | |||
Mucoadhesive buccal films embedded with antiviral drug loaded nanospheresBandar E Al-dhubiabDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, KSAAcyclovir loaded nanospheres embedded mucoadhesive film have been developed as potential drug delivery system and evaluated both ex vivo and in vivo. Poly (lactic-co-glycolic acid) nanospheres were formulated and impregnated in films prepared with varying concentrations of hydroxyethyl cellulose and eudragit RS PO. The prepared formulations (F1-F4) were evaluated by ex vivo permeation studies using rabbit mucosa in order to select the optimum formulation for further studies. In vivo studies were carried out in rabbits to assess the pharmacokinetic profile of acyclovir when delivered from mucoadhesive buccal films and its control. Ex vivo studies (6 h) indicate significant difference in permeation rate of acyclovir from mucoadhesive films (F3 > F4 > F2 > F1), suggesting the release and/or permeation of acyclovir is influenced by the film composition used. SEM images showed the nanospheres were embedded uniformly in the films. In vivo data demonstrated significant absorption (Cmax ~360.93 ng/mL; P<0.0001), prolonged duration (Tmax 6 h) and greater AUC0-α (~5 folds, P<0.0001) with buccal films in comparison to oral solution (control). The results showed Keywords: Acyclovir, buccal delivery, eudragit, ex vivo, in vivoMucoadhesive buccal films embedded with antiviral drug loaded nanospheresBandar E Al-dhubiabDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, KSAAcyclovir loaded nanospheres embedded mucoadhesive film have been developed as potential drug delivery system and evaluated both ex vivo and in vivo. Poly (lactic-co-glycolic acid) nanospheres were formulated and impregnated in films prepared with varying concentrations of hydroxyethyl cellulose and eudragit RS PO. The prepared formulations (F1-F4) were evaluated by ex vivo permeation studies using rabbit mucosa in order to select the optimum formulation for further studies. In vivo studies were carried out in rabbits to assess the pharmacokinetic profile of acyclovir when delivered from mucoadhesive buccal films and its control. Ex vivo studies (6 h) indicate significant difference in permeation rate of acyclovir from mucoadhesive films (F3 > F4 > F2 > F1), suggesting the release and/or permeation of acyclovir is influenced by the film composition used. SEM images showed the nanospheres were embedded uniformly in the films. In vivo data demonstrated significant absorption (Cmax ~360.93 ng/mL; P<0.0001), prolonged duration (Tmax 6 h) and greater AUC0-α (~5 folds, P<0.0001) with buccal films in comparison to oral solution (control). The results showed Anahtar Kelimeler: Acyclovir, buccal delivery, eudragit, ex vivo, in vivoBandar E Al-dhubiab. Mucoadhesive buccal films embedded with antiviral drug loaded nanospheres. Turk J Pharm Sci. 2016; 13(2): 105-123 Corresponding Author: Bandar E Al-dhubiab, Saudi Arabia |
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