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Med Bull Sisli Etfal Hosp. 1995; 29(3): 30-35 | |||
Menopozda Estradiol Valerat/Siproteron Asetat ve Tibolon Erken Dönemde Klinik ve Yan Etkilerinin AraştırılmasıMelahat Kesim, Figen Taşer, Altuğ Bağcı, Kenan ÇalışkanŞişli Etfal Hastanesi 3. Kadın Hastalıkları ve Doğum KliniğiAMAÇ: Menepozal dönemde hipoöstrojeneminin yol açtığı semptomlarla başvuran olgularda Estradiol valerat-Siproteron asetat ve Tibolon kullanımının kısa dönemde etkisinin gösterilmesi istendi. Short Term Clinical and Side Effects of Estradiol Valerate, Siproteron Acetate and Tibolon Use in The Menopausal PeriodMelahat Kesim, Figen Taşer, Altuğ Bağcı, Kenan ÇalışkanŞişli Etfal Hastanesi 3. Kadın Hastalıkları ve Doğum KliniğiOBJECTIVE: in this study we aimed to show the effect of Estradiol Volerate-Siproterone Acetate and Tibolon use in patients who are at menopausa and who have been admitted to the hospital with symptoms resulted from hypoestrogenemia.
MATERIALS AND METHODS: in this study we have included 66 patients. To 36 of patients we have administered 2 mg estradiol-17 valerate for 2 days and 2 mg Estradiol-17 Valerate 1 mg Siproteron Acetate for the following 36 days. We stopped the drug treatment for 7 days and continued the same the next 3 months. To the second group consisted of 30 patients; we have given 2.5 mgldaily Tibolon (oral) continously. We measured the blood levels of SGOT, SGPT. ALP-Urea, and creatinin before and after treatment. We scored the climacteric complaints befor and after treatment. We evaluated the ejfects of both drugs on the relief of symptoms and compared each group with each other. RESULTS: We have observed that both effective forthe relief of symptoms such as flushing, paresthesia, vertigo.fatigue, and nervousness in a short period of time. (p<0.01) We have found that Estradiol Valerate-Siproterone Acetate is effective (p<0.05) and Tibolon is less effective for the symptoms like insomnia, depression, arthralgia, myalgia, headache, palpitations, pollakuria, and dry skin. In short term drug treatment there wasn’t any meaningful difference between the two groups on improvement (p>0.05). Melahat Kesim, Figen Taşer, Altuğ Bağcı, Kenan Çalışkan. Short Term Clinical and Side Effects of Estradiol Valerate, Siproteron Acetate and Tibolon Use in The Menopausal Period. Med Bull Sisli Etfal Hosp. 1995; 29(3): 30-35 Sorumlu Yazar: Melahat Kesim, Türkiye |
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