Online Makale
Online Hizmetlere Toplu BakışSisli Etfal Tip Bülteni
Med Bull Sisli Etfal Hosp. 2018; 52(4): 310-312 | DOI: 10.14744/SEMB.2017.75436 | |||
Takrolimusa Bağlı Aldosteron Rezistansı Olgu SunumuFeyza Bayraktar, Yener Koç, Taner Baştürk, Barış Hasbal, Tamer Şakacı, Elbis Ahbap, Mahmud Islam, Perin Nazif, Abdulkadir ÜnsalŞişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, İstanbul - TürkiyeAmaç: Takrolimus ile daha sık görülmekle birlikte kalsinörün inhibitörlerinin hiporeninemik hipoaldosteronizm benzeri tablo geliştirerek hiponatremi ve hiperkalemi gibi elektrolit bozukluklarına yol açabildiği bilinmektedir. Aldosterone Resistance Due to Tacrolimus: A Case ReportFeyza Bayraktar, Yener Koç, Taner Baştürk, Barış Hasbal, Tamer Şakacı, Elbis Ahbap, Mahmud Islam, Perin Nazif, Abdulkadir ÜnsalDepartment of Nephrology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, TurkeyAlthough more common with tacrolimus, it is known that calcineurin inhibitors may induce the development of electrolyte disorders such as hyponatremia and hyperkalemia by causing a hyporeninemic hypoaldosteronism-like syndrome. We present a 32-year-old female renal transplant patient who admitted to clinic with hyponatremia and hyperkalemia. Normal anion gap metabolic acidosis and renal tubular dysfunction were detected and after other reasons were excluded, it was considered as electrolyte disorder due to tacrolimus. No response was detected after tacrolimus conversion to everolimus and considering tubular dysfunction due to aldosterone resistance, we initiated fludrocortisone therapy and electrolyte disorders rapidly improved. Fludrocortisone therapy should be considered when hyponatremia and/or hyperkalemia due to tacrolimus are detected in renal transplant patients. Keywords: Hyponatremia, renal transplantation; tacrolimus.Feyza Bayraktar, Yener Koç, Taner Baştürk, Barış Hasbal, Tamer Şakacı, Elbis Ahbap, Mahmud Islam, Perin Nazif, Abdulkadir Ünsal. Aldosterone Resistance Due to Tacrolimus: A Case Report. Med Bull Sisli Etfal Hosp. 2018; 52(4): 310-312 Sorumlu Yazar: Feyza Bayraktar, Türkiye |
|