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North Clin Istanb. 2022; 9(3): 282-285 | DOI: 10.14744/nci.2020.66049 | |||
Allojenik hematopetik kök hücre transplantasyonu sonrasi gelişen toksoplazma ensefalitiFeyza Izci Çetinkaya1, Necati Mumcu1, Gamze Kalin Unuvar1, Aysegul Ulu Kilic1, Leylagul Kaynar21Erciyes Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Anabilim Dalı, Kayseri2Erciyes Üniversitesi Tıp Fakültesi Hematoloji Anabilim Dalı, Kayseri Giriş: Toksoplazma ensefaliti hematopoietik kök hücre transplantasyonu (HKHT) sonrası nadir görülen ancak sıklıkla yaşamı tehdit eden bir enfeksiyon hastalığıdır. Bu gibi durumlarda erken teşhis ve tedaviye erken başlanması hayati önem taşır. Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantationFeyza Izci Çetinkaya1, Necati Mumcu1, Gamze Kalin Unuvar1, Aysegul Ulu Kilic1, Leylagul Kaynar21Department of Infectious Diseases, Erciyes University Faculty of Medicine, Kayseri, Turkiye2Department of Hematology, Erciyes University Faculty of Medicine, Kayseri, Turkiye Cerebral toxoplasmosis is a rare but often life-threatening infection after hematopoietic stem cell transplantation (HSCT). In such cases, early diagnosis and initiation of treatment are vital. We describe a case of cerebral toxoplasmosis in a patient who underwent HSCT for acute myeloid leukemia. Infection was diagnosed with polymerase chain reaction (PCR) test of cerebrospinal fluid and cranial magnetic resonance imaging scan. The patient treated with trimethoprim-sulfamethoxazole and clindamycin combination. However, she died from nosocomial infection after 15 days of treatment. This life-threatening infection should be considered in a patient who is post-HSCT present with neurologic symptoms and brain lesions. PCR is an important and rapid diagnostic tool for toxoplasmosis. Cranial imaging scan and PCR should be used together to diagnosed. Keywords: Allogeneic stem cell transplantation, encephalitis; toxoplasmosis.Feyza Izci Çetinkaya, Necati Mumcu, Gamze Kalin Unuvar, Aysegul Ulu Kilic, Leylagul Kaynar. Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. North Clin Istanb. 2022; 9(3): 282-285 Sorumlu Yazar: Feyza Izci Çetinkaya |
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