Lansoprazole as an uncommon cause of anaphylaxis: What to give next?

Attila Aydın¹, Sedat Bilge², Tolga Düzenli³, Harun Aslan⁴, Güçlü Aydın²
¹Department of Emergency Medicine, Acibadem Hospital, Istanbul, Turkey
²Department of Emergency Medicine, Gulhane Training and Research Hospital, Ankara, Turkey
³Department of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
⁴Department of Internal Medicine, Koc University Hospital, Istanbul, Turkey

Proton pump inhibitors (PPIs) are one of the most prescribed drugs worldwide. Anaphylactic reactions of PPIs are rare; however, several cases have been reported. Here, we report a rare case of anaphylaxis that occurred immediately following lansoprazole intake. Following the successful management in the emergency department, skin prick and oral controlled challenge tests were performed to evaluate cross-reactivity. Thereafter, lansoprazole was switched to pantoprazole, which was well tolerated. Skin prick and oral controlled challenge tests can be performed for determining the cross-reactivity of PPIs to prevent adverse reactions.

Keywords: Anaphylaxis, cross-reactivity; lansoprazole; proton pump inhibitors.

Attila Aydın, Sedat Bilge, Tolga Düzenli, Harun Aslan, Güçlü Aydın. Lansoprazole as an uncommon cause of anaphylaxis: What to give next?. North Clin Istanb. 2019; 6(3): 315-316

Sorumlu Yazar: Tolga Düzenli, Türkiye

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