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Kafkas J Med Sci. 2018; 8(1): 35-38 | DOI: 10.5505/kjms.2018.44274 | |||
Hipertiroidilerde Reaksiyon Zamanının Oddball Paradigması ile AraştırılmasıNazan Dolu1, Seval Keloğlan Müsüroğlu2, Leyla Şahin3, Kürşad Ünlühizarcı4, Mustafa Tayfun Turan51Erciyes Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Kayseri2Amasya Üniversitesi Sağlık Yüksekokulu, Hemşirelik Bölümü, Amasya 3Mersin Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Mersin 4Erciyes Üniversitesi Tıp Fakültesi, Endokrinoloji Anabilim Dalı, Kayseri 5Erciyes Üniversitesi Tıp Fakültesi, Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Kayseri Amaç: Tiroid hormonları beyinde fizyolojik ve bilişsel işlevler için oldukça önemlidir. Tiroid bezinden aşırı tiroid hormonu üretimi ile karakterize olan hipertiroidizmin bilişsel işlevlerde değişikliklere neden olduğu bilinmektedir. Bu çalışmada, işitsel uyaranlara reaksiyon zamanı ölçülerek hipertiroidi’nin bilişsel süreçten kaynaklanan motor yanıt üzerine etkisi araştırıldı. Research of the Effect of Hyperthyroidism on Reaction Time Using the Oddball ParadigmNazan Dolu1, Seval Keloğlan Müsüroğlu2, Leyla Şahin3, Kürşad Ünlühizarcı4, Mustafa Tayfun Turan51Erciyes University Faculty of Medicine, Department of Physiology, Kayseri, Turkey2Amasya University School of Health, Department of Nursing, Amasya, Turkey 3Mersin University Faculty of Medicine, Department of Physiology, Mersin, Turkey 4Erciyes University Faculty of Medicine, Department of Endocrinology, Kayseri, Turkey 5Erciyes University Faculty of Medicine, Department of Mental Health and Disease, Kayseri, Turkey Aim: Thyroid hormones are so important for the normal physiological functions and the cognitive functions of brain. It is known that hyperthyroidism, the presence of excessive thyroid hormone produced by the thyroid gland, causes changes in cognitive functions. In this study, we have examined the effect of hyperthyroidism on motor response that result from this cognitive process by measuring reaction time to auditory stimuli. Material and Method: The study was conducted on newly diagnosed hyperthyroid patients (n=20) and healthy controls (n=20). The reaction time was evaluated in an auditory oddball paradigm. For that purpose, participants have been listened to 160 sound stimuli (120 standards, 40 targets). We asked them to press the button under their right hand when they hear the target sounds. The elapsed time between the presentation of the stimulus and the subsequent pressing button has been defined as reaction time. Results: Reaction time was significantly prolonged in the hyperthyroid group compared with the control group (p≤0.001). Conclusion: Hyperthyroid patients had prolonged perception time and significant decrease on attention and concentration. They can be result in prolonged reaction time because of impaired motor functions. Keywords: hyperthyroidism, Oddball paradigm, reaction time, human; cognitionNazan Dolu, Seval Keloğlan Müsüroğlu, Leyla Şahin, Kürşad Ünlühizarcı, Mustafa Tayfun Turan. Research of the Effect of Hyperthyroidism on Reaction Time Using the Oddball Paradigm. Kafkas J Med Sci. 2018; 8(1): 35-38 Sorumlu Yazar: Seval Keloğlan Müsüroğlu, Türkiye |
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