A Case of Living Donor Liver Transplantation due to Hepatic Failure cause of Isotretinoin Therapy

Sencan Acar¹, Serafettin Yazar², Ahmet Kargi², Ramazan Donmez², Serdar Aslan², Kamil Yalcin Polat³, Cigdem Arikan³, Murat Akyildiz³
¹Department of Gastroenterology and Organ Transplantation Center, Sakarya University School of Medicine
²Department of General Surgery and Organ Transplantation Center, Memorial Atasehir Hospital
³Department of Pediatric Gastroenterology and Organ Transplantation Center, Koc University School of Medicine

Isotretinoin is a widely used in acne treatment. It has been some side effects. This drug may rarely cause severe liver failure.
Thirty-five year old woman, liver function tests significantly increased 25 days after start to using isotretionin. Other reasons that cause acute liver failure was investigated and there was not found any other reason. During follow-up period in our hospital, the bilirubin and INR levels was not decreased. The liver biopsy showed that widespread necrosis. Finally, the patient underwent living donor liver transplantation.
Isotretionin treatment may not be innocent. We recommend that the medicine be used only in well-selected patients and by monitoring.

Keywords: hepatic failure, isotretionin, liver transplantation

Sencan Acar, Serafettin Yazar, Ahmet Kargi, Ramazan Donmez, Serdar Aslan, Kamil Yalcin Polat, Cigdem Arikan, Murat Akyildiz. A Case of Living Donor Liver Transplantation due to Hepatic Failure cause of Isotretinoin Therapy. J Turk Acad Dermatol. 2020; 14(2): 0-0

Sorumlu Yazar: Sencan Acar, Türkiye

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