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Haydarpasa Numune Med J. 2022; 62(4): 377-382 | DOI: 10.14744/hnhj.2020.26122 | |||
Reducing Neointimal Hyperplasia in Experimental Carotid Balloon Damage Model with Oral Administration of CilostazolHasan Murat Arslan1, Perçin Karakol2, Ali Vefa Özcan31Department of Cardiovascular Surgery, Istanbul Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Türkiye2Department of Plastic, Reconstructive and Aesthetic Surgery, Health Science University Bağcılar Training and Research Hospital, Istanbul, Türkiye 3Department of Cardiovascular Surgery, Pamukkale University Education Practice and Research Hospital, Denizli, Türkiye INTRODUCTION: Percutaneous revascularization is one of the interventions through which results are obtained quite quickly among the current treatment of blockage artery diseases. In fact, the success achieved is lower than expected due to stenosis formation and spontaneous thrombosis. Vascular endothelial damage after endovascular interventions causes it to become a sticky surface for leukocytes and platelets, the distortion of the normally smooth surface through which the blood moves nonstop causes an increase in adhesion and procoagulant activities and permeability. While many cytokines, vasoactive molecules, and growth factors are released intermittently, if the inflammatory response is not suppressed in some way, the accumulation of extracellular matrix occurs with smooth muscle cell migration and proliferation in the vascular wall. This process, known as neointimal hyperplasia, has become a nightmare for many surgeons. As the known physiopathological mechanism of restenosis began to be understood, many pharmacological agents, mechanical agents were developed to prevent this process and tested with animal and human clinical trials. In our study, we aimed to show the inhibitive effect of cilostazol on neointimal hyperplasia by giving the experimental animal model an oral way. Hasan Murat Arslan, Perçin Karakol, Ali Vefa Özcan. Reducing Neointimal Hyperplasia in Experimental Carotid Balloon Damage Model with Oral Administration of Cilostazol. Haydarpasa Numune Med J. 2022; 62(4): 377-382 Sorumlu Yazar: Perçin Karakol, Türkiye |
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