Does Suppression Of Tsh Affect The Mean Platelet Volume? Retrospective Case Control Study

INTRODUCTION: There have been reports that the mean platelet volume changes in the way of increasing or decreasing in inflammatory diseases. We also wanted to investigate whether there is such a change in the mean platelet volume in thyroid diseases.

METHODS: The data of 1410 patients admitted to the endocrine outpatient clinic were reviewed retrospectively. Age, sex, thyroid disease diagnoses, TSH(μIU/ml), fT3(pg/ml), fT4(ng/dl), MPV(fl) values were recorded. The patients were divided into three groups according to TSH levels and their diagnosis
RESULTS: This study included 1410 patients who were admitted to our endocrine outpatient clinic with a preliminary diagnosis of thyroid. 75.2% of the patients were female and 24.8% were male. The mean age of all patients was 47.87. The mean and standard deviation value of MPV(fl) was 7.49±1.25. We divided the patients into 3 according to their TSH levels: those with TSH values less than 0.35 μIU/ml, those with TSH values 0.35-4.94 μIU/ml and TSH values 4.94 μIU/ml ' greater than.There was no significant correlation between MPV and TSH (p=0.19).
At the subgroups according to the diagnosis; (subacute thyroiditis, Graves disease, toxic adenoma, toxic multinodular goiter, hypothyroidism, tsh suppression in pregnancy, thyroid cancer, euthyroidism, suppressed TSH due to excessive drug use) there was no significant correlation between MPV and TSH (p=0.11, p=0.56, p=0.50, p=0.06, p=0.14, p=0.53, p=0.33, p=0.30, p=0.91 respectively).
DISCUSSION AND CONCLUSION: Is MPV a biomarker or can it play a role in thyroid diseases? According to our study, MPV is not considered as a suitable biomarker for thyroid diseases.