Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity

Farah Dayana Zahedi¹, Nik Mohd Hazleigh Nik Hussin², Salina Husain¹, Ramesh Kumar³, Balwant Singh Gendeh¹
¹Department Of Otorhinolaryngology-head And Neck Surgery Faculty Of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
²Department Of Otorhinolaryngology-head And Neck Surgery Faculty Of Medicine, Universiti Teknologi Malaysia, Selangor, Malaysia
³Neurosurgery Unit, Department Of Surgery Faculty Of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

Introduction: Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is a rare variant of the sinonasal undifferentiated carcinoma (SNUC). The histological classification has implications on its management.

Case report: We report a case of a 32 year old lady who presented with progressive nasal obstruction due to a sinonasal tumour. Endoscopic excisionwas performed and histopathologicall examination confirmedPSNPC with positive Epstein Barr virus insitu hybridisation.

Conclusion: Identification and recognition of PSNPC as a separate clinicopathological entity from SNUC is important as it dictates the management of this rare variant. Immunohistochemical analysis is invaluable in this endeavor.

Keywords: paranasal sinus, sinonasal, undifferentiated carcinoma, Epstein-Barr virus, nasopharynx

Farah Dayana Zahedi, Nik Mohd Hazleigh Nik Hussin, Salina Husain, Ramesh Kumar, Balwant Singh Gendeh. Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity. Eastern J Med. 2017; 22(2): 70-73

Sorumlu Yazar: Farah Dayana Zahedi, Malaysia

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