Which hemogram parameter is more cautionary in euthyroid patients with gestational diabetes mellitus

INTRODUCTION: The aim this study was to compare the various hemogram parameters in euthyroid patients with GDM and healthy pregnant controls and to determine wich parameter is more cautionary for Gestational diabetes mellitus diagnosis.
METHODS: Fifty three pregnant women clinically diagnosed as GDM were recruited from the Endocrinology Department between December 2014 and May 2015. The age, gestational age and body mass index (BMI)-matched thirty five healthy pregnant women as control group were recruited from the Obstetrics and Gynecology Department at same period. The serum samples were obtained after overnight fasting, at the time of OGTT for the analysis and analyzed within 1 h of collection.The level of significance was established by using the student t-test for normally distributed values and Mann Whitney U test for abnormally distributed values. Correlation analysis was determined by using Spearman's rank correlation coefficent. A receiver-operating characteristic (ROC) analysis was conducted to specify the best cut-off value to predict the outcome.
RESULTS: Statistically significant relationships with platelet count, platelet distribution width, lymphocyte count, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), red cell distribution width (RDW) and GDM disease were found (p; 0.000, 0.000,0.000, 0.000, 0.000, 0.007 respectively). Platelet distribution width had higher sensitivity and specificity than other parameters.
DISCUSSION AND CONCLUSION: In conclusion, our study states that in prediction of GDM, the parameters such as PLR, NLR and especillay PDW are more significant than the others and draws attention to the inflammation in the pathogenesis.