Modality for Disseminated Intravascular Coagulation and Current Treatment

Disseminated Intravascular Coagulation (DIC) is a systemic syndrome that causes thrombosis in small and medium-diameter vessels as a result of disruption of hemostatic balance by several reasons, and progresses with the consumption of thrombocyte and coagulation factors, severe hemorrhage and impaired organ perfusion as a result of activation of disseminated intravascular coagulation mechanism. DIC is always a complication that occurs together with some diseases and various secondary pathological conditions. The tissue factor which occurs as a result of tissue factor firstly activates the coagulation cascade; and overproduction of thrombin forms the basis of pathogenesis of DIC. The clinical course of DIC is generally under the influence of the underlying etiologic factor. There is not a laboratory test diagnosing DIC alone; however, the laboratory findings are indispensable for diagnosis. Treating the disease causing DIC and predominant signs of bleeding or thrombosis in clinical table, and conducting prophylaxis for preventing repetitions in chronic DIC cases are the main steps of treatment.