Effect of Acetaminophen on Viability of HeLa Cells

Gökhan Görgişen¹, İsmail Musab Gülaçar¹, Ersoy Öksüz²
¹Department of Medical Biology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey
²Division of Pharmacology, Malatya Training and Research Hospital, Malatya, Turkey

INTRODUCTION: Acetaminophen is a widely used analgesic to release pain and reduce fever. Overdose medication could lead to serious medical conditions such as hepatotoxicity and liver failure. In addition to its cytotoxicity effects, it has an anti-proliferative effect in human cancer cells. In this study it is aimed to determine the cytotoxic effect of acetaminophen in HeLa cells.
METHODS: In this perspective, HeLa cells were treated with different concentrations of acetaminophen at three different exposure times. Cell viability was determined by MTT analysis.
RESULTS: Results showed that acetaminophen inhibited viability of HeLa cells. Its cytotoxic effect depends on exposure time and concentration.
DISCUSSION AND CONCLUSION: Prolonged exposure of acetaminophen led to decrease in cell survival even at minimum concentrations.

Keywords: Acetaminophen, Paracetamol, Cervix carcinoma, HeLa cells, Apoptosis

Gökhan Görgişen, İsmail Musab Gülaçar, Ersoy Öksüz. Effect of Acetaminophen on Viability of HeLa Cells. Eastern J Med. 2019; 24(1): 53-56

Sorumlu Yazar: Gökhan Görgişen, Türkiye

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