Eurasian Journal of Emergency Medicine

A CASE OF METHANOL POISONING [JAEM]
JAEM. 2008; 7(1): 33-34

A CASE OF METHANOL POISONING

Cemil Kavalcı, Y. Çevik, M. Özer
Atatürk Eğitim Ve Araştırma Hastanesi Acil Servis, Ankara, Turkey

Methanol is produced by the distillation of the wood. Its poisoning happens either by mixing with whisky accidentally or consciously by suicidal purposes. Its half-life is 14-20 hours after mild toxicity, 24-30 hours after severe toxicity. It may cause severe ocular and neurological damage after severe toxicity. Treatment parameters are gastric lavage, fomepizole, ethanol and hemodialysis. In this presentation we aimed to review methanol poisoning and its results.
A 28-year-old male patient admitted to the emergency department with the complaints of blurred vision and sensation of tingling. It was learned from his history that he took 200 mL of cologne and 10 tablets of akineton® for suicidal purposes. In the physical examination, his overall position was good, conscious, oriented and cooperated. His blood pressure was 120/80 mmHg, pulse was 88/min and respiration rate was 14/min. His visual acuity was evaluated as 0.6. His laboratory parameters are: pH: 7.28, pO2: 131.1, pCO2: 30.5, HCO3: 20.8 in blood gas analysis; AST: 197 U/L, ALT: 141 U/L, ALP: 188U/l, GGT: 252 U/L, LDH: 248 U/L in biochemical evaluation.
The patient was accepted as methanol poisoning and given fomepizole as 15 mg/kg loading, and then three times 10 mg/kg every 12 hours. Then, 20% ethanol solution was given as 0,6 g/kg loading, 0,11 g/kg every hour. 38 hours after the admission he was asymptomatic and discharged with advises.

Keywords: fomepizole, methanol, poisoning


OLGU SUNUMU: METANOL ZEHİRLENMESİ

Cemil Kavalcı, Y. Çevik, M. Özer
Atatürk Eğitim Ve Araştırma Hastanesi Acil Servis, Ankara

Metanol odunun distilasyonu ile elde edilir. Zehirlenmesi genellikle ya viskiye karışmasıyla kazara ya da bilinçli olarak intihar amacıyladır. Hafif toksisiteden sonra serum yarılanma ömrü 14-20 saat, şiddetli toksisiteden sonra 24-30 saattir. Tedavide gastrik lavaj, fomepizol, etanol ve hemodializ kullanılır. Bu çalışma ile olgu eşliğinde metanol zehirlenmelerinin gözden geçirilmesi amaçlanmıştır.
28 yaşında erkek hasta acil servisimize bulanık görme ve sağ bacağında karıncalanma şikayeti ile başvurdu. Anamnezinden yaklaşık 8 saat önce suisid amaçlı 200 cc kolonya ve 10 adet akineton içtiği öğrenildi. FM’de genel durumu iyi, bilinç açık, oryante, koopere TA: 120/80 mmHg, Nb: 88/dk SS: 14/dk idi. Göz konsültasyonunda görme 0.6 olarak değerlendirildi.
Laboratuvar değerlendirmesinde AKG’de pH: 7.28, pO2: 131.1, pCO2: 30.5, HCO3: 20.8, biyokimyada AST: 197 U/L, ALT: 141 U/L, ALP: 188 U/L, GGT: 252 U/L, LDH: 248 U/L, diğer parametreler normaldi.
Hasta metanol intoksikasyonu kabul edilerek fomepizol 15 mg/kg yükleme, 12 saatte bir 10 mg/kg idame 3 kez verildi. %20’lik etanol yükleme dozu 0,6 g/kg ve idame dozu saatte 0,11 g/kg’dan verildi. Hasta gelişinin 38. saatinde şikayetlerinin geçmesi üzerine kendi isteğiyle taburcu edildi.

Anahtar Kelimeler: fomepizol, metanol, zehirlenme


Cemil Kavalcı, Y. Çevik, M. Özer. A CASE OF METHANOL POISONING. JAEM. 2008; 7(1): 33-34

Corresponding Author: Cemil Kavalcı, Türkiye


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